P-gp has a vast endogenous and exogenous substrate profile that renders difficulty in drug delivery across the BBB.
These two last effects are difficult to be followed experimentally in the nanoscale, which render difficulties to the comprehension of the whole phenomenon.
The assumption of the presence of colored noise is therefore often much more realistic than assuming white noise, which may render difficulties in implementation.
Arthrodesis of the hip joint offers a stable, painless but immobile hip joint, which makes sitting on a chair and in public transportation difficult and can render difficulties with perineal hygiene.
However, in line with previous research, the findings may also provide further evidence to suggest that health services are under-utilised (thereby rendering difficulties in access irrelevant) by men which has obvious implications for men's health in Australia.
In addition, it was our subjective impression that there would be increased physiologic uptake in the floor of mouth (FOM) muscles which could render difficulties in interpreting FDG-PET/CT examinations in patients with malignant tumours of the head and neck.
Reliability tests for these mechanisms are too long to meet the development time requirement, and the underlying dominant mechanisms cannot be identified, rendering difficulty in design-in reliability for integrated circuit.
Our HIV-negative patient had a longstanding and progressing 10-year's history of rupioid skin lesions and orthopaediac involvement but absence of primary syphilis, renders diagnostic difficulty.
