Suggestions(1)
Exact(2)
All CsA-contacting residues of PPIL1 are conserved and exhibit the same side chain rotamers as observed for CypA in complex with CsA, rendering the active site geometry essentially identical to CypA and other CypA-type cyclophilins.
The gating loop is disordered in many unliganded structures rendering the active site solvent-accessible.
Similar(58)
This caspase requires cleavage of the prodomain to render the active fragment p20.
This led to the suggestion that, when DNMT1 encounters an appropriate DNA substrate containing hemimethylated CpGs, the ZF-CxxC domain is unable to bind, causing the autoinhibitory loop to adopt an alternative conformation that renders the active site accessible.
This model is supported by the observation that deletion of this helix renders the active-state mimetic mutant TAp63αFTL dimeric while deletion had no effect on TAp63α.
% PANI to the electrospinning mixture provides 100 and 70 mV improvements to the ORR onset potential and half-wave potential, respectively, rendering the most active non-precious ORR nanofiber catalysts prepared by electrospinning to date.
This is simply because carbonaceous impurities coated on the surface of the as-received SWCNT bundles are cleaned up, rendering the surfaces more active (Fig. 1a, inset).
The resulting ΔRON isoform is unable to undergo proteolytic cleavage, rendering the protein constitutively active and conferring increased motility to cancer cells [ 68, 69].
We observe that the autophosphorylation of Tyr renders the kinase active by allowing full substrate accessibility to its active site.
The modification of the oil flow into each pad supply groove by means of servovalves renders the bearing active.
An approach designed to overcome this limitation was the construction of inactive cytolysin with built-in biological "trigger" that renders the toxin active in the presence of tumour-specific proteinases.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com