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The specificity of this effect is supported by the observation that intrathecal BoNT-B failed to have any effect after delivery in rats, a finding consistent with a single amino acid variation in rat VAMPI protein rendering resistance to BoNT-B cleavaging activity.
It appears that overexpression of PEG10 leads to an inhibition of apoptosis in hepatic cancer [16] and B-cell ALL and CLL [20], [21], which was demonstrated by either siRNA mediated knock-down of PEG10 leading to apoptosis or by overexpression of the PEG10-RF1 protein in hepatoma cells rendering resistance to apoptosis and promoting cell growth [16].
The elevated expression of ALDH in side population cells might be playing a role in rendering resistance to chemotherapeutic agents.
Similar(57)
In this latter case, methylation of alkanes, as in iso-alkanes, could have decreased the solubility of the aliphatic compounds, which in turns would have rendered resistance to or discouraged biodegradation.
It was clear that the introduction of the Ndi1 protein in the substantia nigra rendered resistance to the deleterious effects caused by rotenone exposure as assessed by the levels of tyrosine hydroxylase and dopamine.
But the technique does hinge on the ability to render resistance nearly fully recessive.
The TAF7LmA expression vector contains two silent mutations in Taf7l cDNA which renders resistance to RNA-mediated silencing by shTAF7L.
All these agents are known to be substrates for the Vaults to render resistance to these drugs.
The reason for their presence might be due to cross-resistance, for example 3TC induced M184I/V but also rendered resistance to FTC.
US law gives terrorism too wide a definition, rendering legitimate resistance to occupation and oppression illegal.
Although the underlying mechanisms rendering anoikis resistance in cancer cells are incompletely understood, our findings provide evidence for a novel role for HMGA1 in mediating this process.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com