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As part of our investigations into mechanisms of estrogen response in the mouse uterine model, we have used an ERα knock-in mouse that carries a mutation in its ERα, rendering it unable to directly bind to DNA, thus restricting it to the tethered mode of ERα-mediated gene responses.
Furthermore, the combinational inhibitory effect of 17-AAG on key molecules of the IGF-IR/Akt/IKK axis was found to induce inactivation of NF-κB transcription factor, a downstream target of this pathway, ultimately resulting in its relocation to the cytoplasm, therefore rendering it unable to exert regulatory control upon a vast number of genes involved in cell proliferation and survival.
What about the inattentive x-ray operators who break your laptop, rendering it unable to boot up?
Callaway and his team began with a vaccine form of the rabies virus that was missing the hook-making gene, rendering it unable to jump between cells.
Complicating matters, the Federal Election Commission, which normally has six commissioners, has four vacancies, rendering it unable to rule on disputes.
Although the government played down fears of radiation leak, Japanese nuclear agency spokesman Shinji Kinjo acknowledged there were still fears of a meltdown — the collapse of a power plant's systems, rendering it unable regulate temperatures and keep the reactor fuel cool.
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The displacement of this age-old tool for telling time and its relocation of its contents has rendered it unable to perform its task.
The C-terminus of α-toxin is believed to bind Ca2+ ions [ 25]; the truncation found in JGS6956 Csp would likely render it unable to bind Ca2+, which may affect its function.
Left alone, the telescope will be able to operate for about three more years before the failure of gyroscopes would render it unable to point at the stars.
Critics alleged that it simply mathematized the obvious and, in searching for universal patterns, ignored important cultural contexts, which thus rendered it unable to predict much of importance; another charge was that the choices the theory sought to explain appeared "rational" only in retrospect.
Additionally, she argues, block-granting Snap would render it "unable to respond automatically to increased need resulting from rising poverty and unemployment during an economic downturn" and would also give individual states the option of placing their own restrictions on the programme.
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