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This attenuation could be an indirect effect due to competition for the molecular targets between the wild type EWSFLI1 present in EWS502 and junction region protein which was ectopically overexpressed, or junction region protein interacting with the full length wild type EWS-FLI1 rendering inactive complexes between the two forms of protein.
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Their hope was that one of the mutations would render inactive the gene that makes the unknown receptor.
This enzyme is rendered inactive in individuals who have alkaptonuria, owing to mutation of the enzyme's gene HGD.
Antihistamines are readily absorbed from the alimentary tract, and most are rendered inactive by monoamine oxidase enzymes in the liver.
It is not just Bin Laden who has been killed or rendered inactive, but pretty much everyone else in the senior and middle ranks of the organisation.
An interesting feature of the genome is that 150 of its genes have been rendered inactive by natural mutation, a process that affects any gene that the organism no longer needs.
'Caged' compounds are biological molecules that are rendered inactive by a protecting (cage) group.
There are hereditary mechanisms whereby once a portion of DNA is rendered inactive in a cell it remains inactive in all of that cell's descendents.
In this situation, the catalyst is rendered inactive and low quality nanotubes are produced, as detected for samples prepared with 0.3 g ferrocene.
The UPR is triggered by three ER stress sensors PERK, IRE1α, and ATF6 which are rendered inactive by binding to GRP78 under non-stressed conditions.
Aspirin, caffeine, cocaine, and methamphetamine all find their way into our urine, sometimes unchanged, other times conjugated and rendered inactive, and on some occasions biotransformed into distinct pharmacological entities called active metabolites.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com