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Alterations in the mechanism that promotes or inhibits the differentiation of the embryonic NPC, like p73 deficiency does, would eventually deplete the pool of embryonic NSC, rendering deficient neurogenic-niches in the adult mice.
Analysis of the neurogenic niches demonstrated that p73-loss depletes the number of neural-progenitor cells, rendering deficient niches in the adult mice.
Variant forms of MBL are very common in certain populations among healthy individuals [ 13], and it is known that alternative immune mechanisms can replace the function of MBL [ 32] thereby rendering deficient individuals immune competent.
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In knocking out the orexigen ghrelin, mutant mice were also rendered deficient in the anorexigen obestatin.
5 7 Human cells rendered deficient for ATG16L1 by siRNA display the same phenotype.
Yaa mice rendered deficient in H-2K/D, Tap1, or CD8α was not as profound as that observed in β2m° BXSB.
The physiological roles of STATs have been elucidated by analysis of mice rendered deficient in STAT genes.
Here, we show that BWF1 mice rendered deficient in β2m exhibit markedly increased renal disease with reduced survival, despite reduced serum IgG and IgG2a levels in early life.
As shown in Figure 5G, 4-OH-TAM stimulated profiferathen of the control TamR cells, whereas cells rendered deficient in ABCG2 became sensitive to growth suppression by 4-OH-TAM.
Interestingly, in cells rendered deficient in sulfated HS by treatment with chlorate, stimulation by FGF-2 failed to cause the phosphorylation of FRS2.
In concordance with this observation, New Zealand Black mice, which suffer from mild lupus, also develop severe disease when rendered deficient in TNF [ 10].
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