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Furthermore, tolDCs suppressed mature DC-induced T cell proliferation, interferon γ and interleukin 17 production, and rendered T cells hyporesponsive to further stimulation.
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Pre-activation of T cells by IL-15, which by-passes the need for CD25, renders T cells resistant to suppression by MM tumour cells.
Oxidative stress-induced modification to selective molecules involved in T cell receptor (TCR) signaling can render T cells hyporesponsive to activating stimuli [219].
These studies demonstrated that PP14 mediates its anti-inflammatory activity by elevating T cell activation thresholds, thereby rendering T cells less sensitive to a given level of T cell receptor (TCR) stimulation [13].
Axin2 and DKK-1 are inhibitors of Wnt signalling and it is possible that an active inhibition of these antagonists renders T cells more sensitive to Wnt signalling at a later stage after T cell activation.
It regulates T-cell activation and proliferation and induces Bcl-2 to render T cells resistant to apoptosis.
A defect in costimulation may render T cells refractory to TCR-mediated apoptosis or to tolerance-inducing signals.
Similar reagents are being developed to render T cells 'invisible' to a commonly used conditioning antibody, alemtuzemab.
This measure renders t scores and is widely used with repeated assessments of its reliability and validity (14).
There have also been attempts to render T cells resistant to immunosuppressive agents, and such cells could have interesting niche applications.
This may render T sperm more sensitive to certain types of extenders that are commonly employed in cooled storage semen [ 38].
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