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Whereas an anti-betacellulin antibody in combination with Iressa increased the anti-proliferative effect in resistant cells, ligands such as heregulin and betacellulin rendered sensitive SKBR3 cells resistant to Iressa.
To determine whether radioresistant cells could be rendered sensitive by targeting the DNA repair pathway, the PARP inhibitor niacinamide was added to cells prior to irradiation.
In this fashion, tumors predicted to be therapy resistant might be rendered sensitive to the original therapy and treatment efficacy could be increased.
Thus as predicted by our hypothesis, cells with wild-type expression of NEMO that are rendered sensitive to TNF-induced apoptosis by NF-κB blockade (i.e., 'NF-κB-deficient' cells) do not require RIP1 to undergo apoptosis.
This is the first report to show that newly established cell lines that are resistant to classical chemotherapeutic agents are rendered sensitive when the drug enters the cell as a drug monoclonal antibody carrier.
RA SF T cells were resistant to glucocorticoid-induced apoptosis when cultured in the presence of monocytes but were rendered sensitive to all three tested compounds upon SF isolation.
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Due to the increasing usage of the cloud computing architecture, computer systems are facing many security challenges that render sensitive data visible and available to be counterfeited by malicious users and especially intruders.
Additional comparative studies using autoimmune-prone and nonautoimmune mice strains with different genetic backgrounds will help determine the contribution that xenobiotic exposure makes in rendering sensitive populations susceptible to autoimmune diseases.
This study therefore demonstrates for the first time that inhibition of SphK-1 rendered RAW macrophages sensitive to infection.
Shear stable, sodium caseinate stabilized emulsions were rendered shear sensitive by the addition of Tween 20.
We have rendered GFP sensitive to proteolysis by inserting five amino acids, IEGRS, in loops at position 157, 172, or 189.
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