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For the RNA binding partner we used the 300-mer 5′ domain of HOTAIR previously established to be necessary and sufficient to bind PRC2 3m, as the size of the full HOTAIR lncRNA (2.2 kb) rendered it intractable to study by EMSA.
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By sending large numbers of polymerases to the wrong targets such a mutation may produce diseases that have no single cause, but are the result of hundreds and thousands of improper gene expressions that may seem functionally unrelated and, thus, render it almost intractable.
Will this eventually render it unplayable?
The monstrousness of it renders it unimaginable.
Nothing can render it false.
It phosphorylates cofilin, thereby rendering it inactive.
Finish your movie, and render it.
This will render it totally useless.
It has shown to provide useful results in many complex situations, where the physics of the system involves many degrees of freedom and a multitude of different length scales, generally rendering its numerical treatment on a detailed level computationally intractable.
None have promised to solve homelessness; the current mayor, Willie L. Brown Jr., has called it "intractable".
The primary challenge involved is the computational complexity, that increases to the power of the number of classes, rendering many problems intractable.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com