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The changes of the 3D rendered functional microvasculature were shown in Fig. 5, where the functional vessel density reduction could be observed directly after renal ischemia.
And so in ESCs, where activators maintain expression of pluripotency genes, differentiation genes could simply be off (by default, as it were) until activated by some activators that are rendered functional by virtue of gain (or loss) of a signal.
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It is this feature that rendered biochemical, functional, and structural characterization of membrane proteins difficult for a long time.
A functional overlap can also be expected between mesocarp and seeds regarding GO terms (i.e. abundance of GO terms associated with oil production), and it is probably the reason why our comparative analysis has not rendered clearer functional profiles for these two tissues.
Finally, the well-defined catalytic domains present in LRRK2 render functional assays on this molecule tractable, and suggest that it may be amenable to therapeutic targeting.
Somatic mutations affecting their rearranged immunoglobulin genes were detected, rendering potential functional rearrangements non-functional.
Even if it could not be excluded that the coding sequence could also contain miRNA target sequences that are functional in translation regulation, they would most likely be rendered non-functional by traversing ribosomes during translation.
Firstly, the tyrosine phosphorylation of Gab1 is drastically reduced in mouse embryonic fibroblasts (MEFs) lacking Grb2 or expressing a functionally impaired Grb2 protein in which its SH2 domain has been rendered non-functional by the E89K knock-in mutation [ 60].
Recent research (notably cross-species comparisons of gene sequences rendered non-functional by mutations) has greatly strengthened the case that humans and chimpanzees share a common ancestor.
Most loci are rendered non-functional by mutations, but several intact retroviral genes are known in mammalian genomes.
These findings show that the Nts-1 receptor is rapidly rendered non-functional after 15 minutes at a restrictive temperature.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com