Data from animal models show that in utero exposure to a maternal high-fat diet (HFD) renders susceptibility of these offspring to the adult onset of metabolic syndrome.
Although predisposing inversion(s) and translocations rendering susceptibility to rearrangements in the offspring similar to what is known for several genomic disorders have been excluded in the parental chromosomes (Axton 2006; Lupski 2006), alternative mechanisms of CCR formation cannot be fully excluded.
These findings seen in our patient may have been caused by a number of factors including the loose connection of the abomasum to the cranially situated abdominal organs and wall and thus rendering susceptibility to dislocation and bloating, constrictions of the large intestine at the level of the caecum and the proximal loop of the ascending colon, and lack of normal ruminal compartmentalisation.
Recent data suggest that this ROS-generating agent may perturb cellular homeostasis and modulate the various stress-related genes, implicating that the involvement of ROS-dependent ER stress may render the susceptibility of cancer cells to fenretinide-induced apoptosis [16].
One might therefore speculate that the inflammatory milieu, especially reflected by circulating levels of MIF, could render patients susceptibility to an increased inflammatory response [ 28].
These results further support the putative role of these pathways in rendering BC susceptibility.
Such compounds might be valuable tools, not only by inhibiting NagZ and thus rendering increased susceptibility to β-lactams of Gram-negative bacteria harbouring inducible ampC, but also by aiding improved understanding of the binding of selective inhibitors to this family of enzymes and the role played by NagZ in peptidoglycan recycling.
A decrease in the antiviral efficacy for susceptibility renders the antiviral drug less effective.
This cortical malformation may thus confer a susceptibility rendering the affected brain vulnerable to seizures after subsequent injuries such as febrile convulsions or head trauma [ 55, 56].
Twenty-seven miRNAs were mapped and located in 9 T1D susceptibility regions, rendering these miRNAs candidates for T1D susceptibility genes [ 57].
