Sentence examples for render substantial from inspiring English sources

Mutation of these clusters in combination appears to render substantial loss-of-function with regard to β-arrestin interaction strength, despite no apparent reduction in cell surface expression as determined by assessment of proximity to the Kras cell surface marker.

Therefore, the suppression of c-myc expression by oridonin may render substantial therapeutic benefits in colorectal cancer patients by inhibiting the driving activities of c-myc in cell proliferation and cell cycle progression.

In 1802 he rendered substantial help in establishing the life consulate for Bonaparte.

But on Monday, the office of Preet Bharara, the United States attorney for the Southern District of New York, said in a four-page letter to the judge that Mr. Lipsky had rendered "substantial assistance in the investigation and prosecution of numerous other persons".

In addition, although, unmethylated CpG motifs within the plasmid DNA vector have also been shown to contribute to the immunogenicity of DNA vaccines [45], [46], cloning additional CpG motifs or adding CpG-ODN to the DNA vaccine rendered substantial immune responses [47], [48].

Several reports have evaluated changes in renal function following RNU and demonstrated that the decline in renal function may render a substantial number of patients ineligible to receive adjuvant chemotherapy (AC) [ 10– 15].

Some of those shoppers are especially receptive to the proliferation of suits, intricately seamed and rendered in substantial fabrics that look all the more opulent when the beads, appliqués and embroideries are stripped away.

The targeted northern municipality was chosen due to its rural nature, rendering a substantial number of children on high speed roads.

Interpreting the statute as prosecutors and police wished "would have the effect of rendering a substantial amount of otherwise lawful conduct illegal in Illinois," the court wrote.

Any such misclassification will result in a dilution of the estimated associations, which renders the substantial protective influence of pre-adult body fatness in this study even more thought provoking.

At the same time, persons in rural western Uganda already bear a high incidence of pathogens, including HIV (14 ), which renders a substantial proportion of the population immunocompromised and susceptible to opportunistic infections.