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These complex, interwoven factors and their varying extents in any given individual with COPD may make prediction of response to dietary nitrate supplementation difficult, and furthermore may render it challenging to precisely identify a mechanism for exercise enhancement, if it exists.
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The pathogenicity of EMCV in mice certainly renders it challenging for further pre-clinical testing in a traditional mouse models.
Manually assessing a field activity to identify the ergonomic risks is not trivial and often requires extra effort which may render it to be challenging if not impossible.
While it might render previously challenging games too easy, it can also pave the way for games that are much more fast paced.
Another caveat comes from the usage of diuretics which will increase the urinary sodium concentration rendering its interpretation challenging.
However, this same malleability of ESCs also renders it a challenge to obtain in vitro differentiation of ESCs to specific cell types at high efficacy.
A high turnover with some medical devices rendered it a challenge for staff members to gain experience with them and, thus, understand the nuances of their performance.
On the other hand, however, the highest polymorphism of intronic and intergenic sequences should render more challenging the selection of SNPs with flanking sequences with no additional SNPs.
The structural complexity, insolubility and high molecular weight of lignin render its enzymatic degradation challenging but rewarding for microorganisms to gain access and convert the polysaccharides.
These and other changes render milestone identification challenging; the ninth milestone of 1769 was relocated to 151st Street in 1813, but others may have been replaced and old ones ignored.
Despite its power, difficulties in cell identification during analysis of environmental samples might render this approach challenging for certain applications.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com