Thus, although obesity might induce some benefit, these very effects might also render hearts resistant to further protective intervention.
Although these changes might contribute to obesity-dependent protection, they might also render hearts refractory to further protection via receptor stimuli (e.g. δ-OR agonism) targeting the same PI3K-Akt-eNOS signalling.
Inotropic therapy, judicious fluid administration guided by close hemodynamic monitoring together with a trial of treatment with triple hormonal therapy (corticosteroid, vasopressin and thyroid hormone) might have improved cardiac and pulmonary function, rendering heart and lung donation possible.
Hers is a simple rendering, heart-shaped with a childlike angel, displayed on her right forearm.
They demonstrated that overexpression of SIRT1 further promoted cardiac dysfunction, whereas Alcendor showed that moderate overexpression of SIRT1 rendered hearts resistant to oxidative stress-induced damage by paraquat.
A relative increase in β-MHC levels, which commonly occurs in diseased conditions, renders hearts more susceptible to chronic myocardial stress [ 53].
Our hypothesis is that short-term hypertrophic stimulation can render the heart resistant to subsequent hypertrophic stress and slow the progression to heart failure.
Here, we hypothesized that transient short-term hypertrophic stimulation would induce the expression of hypertrophy regression genes and render the heart resistant to subsequent hypertrophic stress, and slow the progression to heart failure, as well.
The deletion of MFN1, MFN2 or OPA1 appears to render the heart less resistant to MPTP opening, and in the case of MFN1 and MFN2, the hearts have been reported to be more resistant to acute IRI.
But a psychologist would also recognize a much more complicated condition, one born of this mad new era in which a pencil-size amount of irradiated cobalt could render the heart of the city uninhabitable for decades to come.
