Sentence examples for render aberrant from inspiring English sources

One of the current hypotheses postulates that in AD, tau-related toxicity may result from its mislocalization to neuronal soma/dendrites and/or excessive phosphorylation that would render aberrant interactions with molecules with which it either would not normally interact or would do so to a lesser extent [ 47].

b Axial CT and c volume-rendering reconstruction reveal an aberrant right upper bronchus and a long distal tracheal stenosis caused by complete cartilage rings.

These mutations render plasma gelsolin susceptible to aberrant proteolysis by furin in the trans-Golgi network, the initial proteolytic event in the formation of 71 and 53 residue fragments that assemble into amyloid fibrils.

Underlying these efforts is the hope that the manifold changes inflicted on cancer cells during the transformation process and the resultant aberrant signaling circuits, render them sensitive to specific proapoptotic stimuli that spare normal cells.

The ability to undergo structural change is due to intrinsic strain within the serpin's tertiary fold, which is utilized for proteinase inhibition but renders the protein susceptible to aberrant folding and self-association.

Using mouse models of HD, the authors demonstrate that striatal astrocytes containing mHTT present altered Kir4.1 channel activity and aberrant extracellular potassium homeostasis rendering striatal neurons hyperexcitable, which possibly account for HD motor symptoms.

Multiple lines of genetic evidence demonstrate that PTEN loss results in aberrant hyperactivation of Akt that renders PTEN-deficient mice to predispose to neoplasia and tumors [ 35].

Thus, any aberrant regulation of MAPK cascades may render cells insensitive to regulatory signals and contribute to tumor genesis [ 24].

Since VEGFR2 is responsible for vascular endothelial proliferation and migration, suppression of VEGF-A-VEGFR2 interaction by soluble HS in the ocular fluid renders protection of the intra-vitreal environment from aberrant invasion of retinal vessels.

TAA comprise a range of self‐derived proteins rendered immunogenic in tumors either by mutation or aberrant expression.

Aberrant methylation can change chromatin structure, rendering DNA binding sites accessible or inaccessible to transcription factors leading to activation or silencing of genes important in cell differentiation and maintenance.