Exact(1)
PCP first applies FS-weights [ 40] to evaluate the reliability of protein interactions and then modifies the PPI network by removing interactions with low FS-weights and including novel indirect interactions with high FS-weights.
Similar(59)
In the following step a threshold can be applied to remove interactions with low weight (and therefore low likelihood).
The Protein Complex Prediction method (PCP) [ 30] uses indirect interactions and topological weight to augment protein-protein interactions, as well as to remove interactions with weights below a threshold.
The weights assigned to each edge represent a valuable information to remove interaction with low informative content.
In this work, we used a library screening approach to reengineer the multi-specific anti-apoptotic protein Bcl-xL to remove its interactions with many of its binding partners, making it a high-affinity and selective binder of the BH3 region of pro-apoptotic protein Bad.
(Since Mars has no magnetic field, its atmosphere would be slowly removed by interaction with the solar wind).
A small fragment of Ii, CLIP, remains in the peptide-binding groove and is removed through interaction with the nonclassical molecule HLA-DM 9.
7, 19– 24 However, removing CHWs from their home environment changes the physical space in which they work (e.g., lighting and facility structure) and the resources they have at hand (e.g., timers, drug supply), removes the interaction with the caretaker as a respected member of the community, and may bias the case mix towards more severely ill children.
We then infer TEDG by removing the indirect interactions with network deconvolution and simplification algorithms ('Materials and methods').
These include: effects on chaperone proteins, which help fold proteins and remove misfolded ones; interactions with caspases, which play a role in the process of removing cells; the toxic effects of glutamine on nerve cells; impairment of energy production within cells; and effects on the expression of genes.
Redundant interactions were removed, along with interactions with identifiers that could not be mapped to gene symbols (Table 1).
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