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It removes candidate fusions with a high number of reads on homologous or repetitive regions.
As noted by Shadforth and colleagues [ 26], the APS approach removes candidate false positive hits whilst maximising true positive matches by selecting weaker scoring peptides that are consistent with higher scoring peptides in the same proteins.
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From the remaining list it removes candidates with non-optimal siRNA duplex stability.
"si-shRNA selector" calculates terminal asymmetry of siRNA and siRNA-like duplex stability and removes candidates with strand asymmetry below 2 kcal/mol.
This procedure is a coarse process that removes candidates highly unlikely to be TFBS.
British universities will be forced to remove candidate's names from their application forms to tackle the danger of "unconscious bias" against students from ethnic minorities.
They generated a list of candidate aspects above a frequency threshold and then removed candidate aspects that do not exhibit aspects-like behavior.
While Yee withdrew his election bid shortly after his arrest, he did so after the deadline for removing candidate statements from the voter guide had passed, the Los Angeles Times reported, noting Yee's stated promises to "guarantee fair elections, expose special interests, and prevent corruption".
Specifically, ARACNe uses the Data Processing Inequality theorem of mutual information, as well as direct knowledge of TF identity, to remove candidate regulatory interactions that are likely to be of an indirect nature [24], [25].
We modeled predictors of being a structured documenter using logistic regression with a stepwise backward elimination algorithm, iteratively removing candidate predictors with a p-value > 0.2.
However, a tight integration of models and software is currently only provided by the Model SEED, and most of the advanced tasks, like model manipulations (reaction direction assignment, adding or removing candidate reactions, modifying the objective function), are limited to experienced users with programming skills.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com