In addition to the ubiquitous U2-type "major" spliceosome that removes the majority of all introns, the U12-type "minor" spliceosome excises a subset of introns containing highly conserved 5' splice site (5'ss) and branch point sequences (BPS) [1], [2], [3], [4].
γ-Secretase exhibits little cleavage specificity and appears to preferentially cleave the substrate's transmembrane "stubs" that have been generated following sheddase cleavage that removes the majority of the substrate's ectodomain.
We have designed a cellular preparation protocol for imaging/profiling MS that removes the majority of the interfering species derived from the cellular growth medium, preserves the basic morphology of the cells, and allows chemical profiling of the diffusible elements of the cytosol.
It is thought that this process of seeding of the peritoneum is directly associated with the production of ascites, evidenced by the reduction of ascites volume when patients undergo debulking surgery or chemotherapy treatment that removes the majority of residual macroscopic disease [ 3, 15].
Edward lived a life of luxury that was often far removed from that of the majority of his subjects.
By using the ≥ 9 cut-off, we removed the majority of genes that failed to reach the p < 0.01 confidence level, which increases our confidence in the proper identification of germline-specific/enriched genes.
We demonstrated that applying the filters could dramatically decrease the discrepancies between the observed and expected distributions of allele fractions, suggesting that the filters successfully removed the majority of technical artifacts (Supplementary information, Figure S1).
The spectrophotometric analysis revealed that the decellularization process removed the majority of the DNA content in the treated tissue compared to the native one (286 ± 83 ng/mg versus 2586 ± 542 ng/mg).
PR IGFBP-2 was not cleaved by most but not all proteases in conditioned media of a range of colon, prostate and breast cancer cell lines (Supplementary Figure S2), suggesting that deletion of residues 114 170 removed the majority of protease IGFBP-2 cleavage sites.
The Associated Press reports that Ortho said it has already removed neonics from the majority of its products used to control garden pests and plans to remove it from all the rest of its products in two to five years.
