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We removed interactions involving miRNAs or genes that were not present in the expression data.
Once each of the gold standards was constructed, we removed interactions without statistically significant associations (in the observational data) according to Fisher's Z-test [ 23] at 5% FDR [ 24, 25].
These mutations did not cause significant structural changes in either the closed or open conformation of MBP, but rather removed interactions in the hinge that shifted the equilibrium of conformational states toward the closed conformation such that the binding affinity could be greatly increased.
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The automated BIND translation process found and removed interaction entries that did not meet minimum requirements as defined by MIMIx.
An interaction effect was seen for the ventricles, though its strength was hard to judge as the exclusion of diagnosis at all but the lowest penalty levels automatically removed interaction from consideration.
This process included removing interactions such as keyword searches and next page requests, as well as those that could straightforwardly be attributed to web crawlers by means of their hostnames.
Further, to remove interactions between reactions by virtue of ubiquitously present 'currency metabolites' such as ATP, ADP, NADP, H2O, CO2, Coenzyme-A etc., matrix rows representing currency metabolites were discarded.
ChIA-PET interactions were additionally filtered to remove interactions between regions ≤1000 bp apart.
In the following step a threshold can be applied to remove interactions with low weight (and therefore low likelihood).
A vacuum layer of more than 10 Å was used to remove interactions between repeated images perpendicular to the tube axis.
This step is necessary to remove interactions starting or ending in genes which have high DTI values with many other genes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com