This strategy of removing all text-mined associations will have removed many genuine interactions that would be useful for prioritization of a novel disease gene association.
This step removed some genuine orphan sense IPACs, but we preferred this conservative approach to focus on IPACs of high confidence.
In our hands, these methods removed several genuine transcripts of interest without removing as large a proportion of the tag sequences as the genome-based approach (data not shown).
From his initial eagerness to remove the genuine social evils of slum housing, Poulson had grown, step by step, into a full-scale criminal.
A drastic alternative would be that of calculating partial correlations 'within' genes (i.e., each gene versus all others, as in some prediction-oriented methods), but this would also remove the genuine interactions at the molecular level, representing gene co-regulations.
Along the way it riffs on the mistaken-identity theme: a picture given in good faith by the City of Nuremberg to Charles I in 1636 as a work by Dürer that's proved to be a copy; a copy of a Veronese that, after grime is removed, emerges as the genuine article.
This clean-up process removed only ~2% of genuine miRNA sequences.
This is likely to remove a few genuine tags because databases of expressed sequences are not complete and splicing, polyadenylation and sequence polymorphisms mean that expressed sequence is not always identical to genomic sequence.
To the degree genuine confounders were removed from the propensity score, the analysis would become increasingly dependent on the ACCE method to capture this larger amount of residual confounding and accurately remove it in order to obtain an unconfounded treatment effect estimate.
It also removes any real incentive for universities and their science departments to make genuine structural reforms, as opposed to palliative policy shifts, to accommodate mothers.
