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We excluded genes that could not be mapped to the gene list G and removed gene sets with less than ten genes.
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To make these long lists of GO terms more intelligible, terms were summarized using semantic similarity measures to remove gene-set and GO term redundancy (see Methods).
To ascertain if the enrichment noted for the MYC and E2F sets was entirely due to the presence of proliferation-associated genes in these sets, we removed genes in the GO "cell cycle" (GO∶0007049) and "cell proliferation" (GO∶0008283) categories from the relevant sets enriched with FDR<0.0001.
Predicted genes with matches to transposable element domains are often removed from gene sets.
To avoid potential errors from name-space issues [ 2], we carefully removed the gene sets containing high percentage of duplicative genes (>10%).
When simulating the metabolic network of a knockout mutant, the activity of each reaction is determined by evaluating its GPR association according to the set of removed genes.
Venter and his colleagues then removed genes one by one to find a minimal set that could sustain life.
In those cases, we removed the gene set from the null distribution or from the group of sets that were tested.
In this approach, the genes of the core gene set were removed from all gene sets without replacement.
In the first one, genes of the core gene set were removed from all gene sets downloaded from MSigDB.
The genes of the core gene set were removed from the gene sets downloaded from MSigDB using two approaches.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com