It may even completely remove a true association between an exposure and outcome of interest.
In this way, it is possible for our method or a method such as SVA that utilizes the inter-sample correlation matrix to remove a true biological signal.
To summarize this aspect, there is a low probability that (weighted) TR removes a true edge within a negative feed-forward loop and neglecting edge signs in TR will therefore have only minor impact on the reconstruction quality.
LoFreq's own Fisher's exact test of strand bias successfully removed all false positives, however it also removed a number of true positives.
Moreover, most of the original carved stones and surviving decorative elements had been removed, making a true "reconstruction" unrealisable.
However, it would also have largely removed any true collective genomic enrichment pattern shared by many TFs.
The authors construct a large random database which has been filtered to remove all true peptides.
Both permutations remove any true biological association between gene sets and the genes they contain.
We believe that using this length threshold, we have significantly reduced the number of possible short false positives without removing a significant number of true-positive short ORFs.
While it is true that removing a few uninhabited trailers and a water tower or two hardly constitutes the "painful sacrifices" that Mr. Sharon has advertised, it was an important first step, one that Mr. Sharon might have delayed under right-wing pressure following the killing of the soldiers.
