We also performed an analysis for East Asian individuals by removing a study conducting on Iraqi(Somi, M. H [12]) from Asian group, the result still stable(G allele vs. A allele:OR, 1.49; 95% CI, [1.12, 1.98]; p = 0.006; GG vs. GA+AA: OR, 1.56; 95% CI, [1.17, 2.08]; p = 0.002).
Sensitivity analysis was performed by removing a study with a specific dose from the analysis at a time to evaluate the stability of the pooled values.
For each sensitivity analysis, we individually removed a single study with the largest OR, the smallest OR, the largest standard error, and the smallest standard error from the meta-analyses.
To assess the influence of each individual study on the pooled ORs, the sensitivity analysis was performed by removing a single study from meta-analysis sequentially.
This is significant because each SNP that is removed from a study due to poor genotype calling is potentially a missed association.
(Of course taking into account that a child will be removed from a study if it is not in the its interests to remain in the study and also that treatments will be adjusted if a child is too unwell to tolerate them).
In order to avoid type II errors, Bonferroni adjustment of the P-values was not performed for multiple comparisons., To test the robustness of the results, sensitivity analysis was performed by removing a single study at a time.
After duplicates were removed, a total of 51 study reports were retrieved for full text screening.
Although there is still a degree of reverse causality to address even with the methodological approach applied here, this study successfully removed a great deal of "microbial signal noise", potentially irrelevant to the microbial origins of CD, and thus focuses the field for more targeted research.
The meta-analysis was not dominated by any individual study, while removing any study at a time made no difference (data not shown).
