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In contrast, the H498A/R637A mutations, located in the putative peptide-binding groove immediately adjacent to the active site, not only remove activity towards TAB1 but also abrogate self-glycosylation.
The grand mean across all concepts was subtracted from the grand mean of each single concept to remove activity not related specifically to it.
In support of this assertion, we replaced the catalytic cysteine residue in the V266E variants with a serine residue to remove activity.
It has been shown that ICA can effectively detect, separate and remove activity in EEG records from a wide variety of artificial sources [ 21].
In other words, by subtracting the 2 responses from each other, it is possible to remove activity fluctuations that are common to the 2 recording sites.
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Performance is higher in the label removal model, where the removed activity labels might be compensated by activity values of the same compound on related assays.
These data sets were made progressively sparser by removing activity records and the models re-learnt.
To explore this issue, we have used two complete data sets to simulate sparseness by removing activity labels progressively.
Excluding voxels responding to scrambled images from the Hexe map further removes activity in low-level visual areas.
By removing activity of the two known regulators mcbR and ssuR in both mutants, only CysR-dependent regulation should remain.
The difference in adenine removing activity between the p.Y151C protein and p.G368D protein may be related to the difference in clinical phenotype.
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