Treatment consists of surgical removal, but recurrences are common.
Remarkably, the authors focused their attention on the rate of incomplete removal and recurrences related to the learning curve of the surgeons and the inappropriate positioning of the surgical instruments, which have been found to be the main factors influencing negative outcome in this particular study.
In contrast, infections of pacemaker leads or other implantable cardiac devices require complete hardware removal, as infection recurrence always occurs, even after a seemingly effective initial treatment.
Therefore, incomplete removal and subsequent recurrence are common.
The benign clinical course following removal, with no recurrence after 2 years, is in accordance with various reports [ 3, 5, 9, 17].
One-hundred and sixty-six patients (69%) had a disease-free interval (DFI) of >12 months between primary tumour removal and first recurrence.
The timing and shape of peaks suggest the occurrence of some triggering event, correlated with primary tumour surgical removal, resulting in recurrence synchronisation, which seems to be especially important for pre-menopausal node-positive patients.
Particular attention is given to the detection of surgically resectable disease as there is now increasing evidence that improvements in survival are achieved by aggressive surgical removal of such recurrences.
Eighteen patients were noted as no clinical data regarding nodal metastatic spreading because the sample used for DNA extraction was obtained during the surgical removal of a local recurrence in individuals who had had a previous lymphadenectomy (14 cases) or a previous metastasectomy for distant recurrence (4 cases).
c At age seven, 18 months following screw removal, there is moderate recurrence of genu valgum and the mechanical axis is in lateral zone +2.
