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Healthy aging depends on removal of damaged cellular material that is in part mediated by autophagy.
However, cell-cycle entry of damaged HSCs promotes DNA repair or the removal of damaged HSCs (Beerman et al., 2014, Wang et al., 2014, Walter et al., 2015).
"We know now that removal of damaged structures in the knee often causes additional damage," Stone says.
Whereas macrophages are employed in the removal of damaged cells, favoring tissue regeneration, they also stimulate specific CD8+ lymphocytes that in turn create additional damage.
DNA-damage-induced apoptosis plays a vital role in the maintenance of genomic stability by the removal of damaged cells.
Removal of damaged or dysfunctional mitochondria by mitophagy has been proved to be an important mitochondrial quality control mechanism.
The removal of damaged bases from substrate by DNA glycosylase would lower the melting temperature of HP.
Removal of damaged regions of the meniscus subsequent to injury impairs knee function and predisposes patients to osteoarthritis.
Selective removal of damaged mitochondria by autophagy has been proposed as a protective mechanism against neuronal toxicant-induced neurotoxicity.
This is followed by removal of damaged region by an exonuclease, resynthesis by DNA polymerase, and nick sealing by DNA ligase.
We hypothesized that RPE, compromised by the toxic components of cigarette smoke, will need to increase removal of damaged intracellular macromolecules.
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