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Because the burial study was a split-plot design, for both anova and regressions that included removal, the block by removal interaction was used as an error to test removal.
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Distribution of SF charge has significant role on the removal and interaction of various metal ions with adsorbent.
Prior to the removal of interaction variables a difference of 0.008 points was observed, p < 0.045.
Prior to the removal of interaction variables a difference of 0.008 points was observed, p < 0.045 (Table 3).
MFG-E8 is an opsonin (bridging protein) that binds to phosphatidylserine on apoptotic cells and facilitates their removal through interaction with integrins on phagocytes.
Therefore, although this de novo-designed metalloenzyme is already within only ∼100-fold of the fastest CA isozyme that has numerous conserved secondary interactions, removal of such interactions yields a mutant native protein with an efficiency that is approximately the same as that of a first-coordination-sphere-only model.
Interaction terms that were not significant in the final model were removed if removal of the interaction term did not result in a significant change in the likelihood ratio test (logistic regression) and partial F-test (linear regression).
The modification however made the compound more selective towards the tankyrases (Table S1) likely due to the removal of interactions with the α-helical regulatory domains of ARTD1 and 2, which is not present in tankyrases (Figure S1 18.
The removal of interactions did not change the significance of main effects.
For this reason the question arises what influence does the addition or removal of interactions (edges in the network) have on our results.
The removal of interactions leads to more parsimonious models whose risk associations have a clearer interpretation.
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