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Clustering analyses clearly showed that bladder cells exhibit a unique transcriptome profile among the different types of plant tissues tested, with a remote similarity to leaf cells (Supplementary information, Figure S13).
Among others, these include novel algorithms to navigate high-dimensional chemical spaces, train similarity calculations on specific compound classes, and detect remote similarity relationships.
Janáček's use of these repeated motifs demonstrates a remote similarity to minimalist composers (Sir Charles Mackerras called Janáček "the first minimalist composer").
A detailed binding site representation at the atomic level is therefore detrimental to the detection of remote similarity between synapsin I and Pim-1 kinase.
The herein predicted remote similarity between ATP-binding sites of Pim-1 kinase and synapsin I could be experimentally validated by an in vitro competition assay.
One might argue that a remote similarity among ATP-binding sites is trivial and that the herein presented data are not surprising.
Similar(31)
In addition, the hit lists when expanded using corresponding UniRef50 cluster members provide an effective way to locate the similar sequences that are already identified by UniRef50 and detect more remote similarities for the query sequence.
The authors have used very powerful analytic tools to detect remote similarities.
Accordingly, most of the other ORFs within this island exhibit remote similarities with phage ORFs in protein sequence databases.
Using fold-recognition, we identified remote similarities between Oluc-19 and the well-characterized family of iLBPs.
However, these alignment-based methods are less effective for identifying remote similarities, e.g., identifying proteins from highly divergent or possibly new 7TMR families.
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