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Remote regulation could fundamentally transform the way regulators interact with employers and the public.
To date, only few studies point to remote regulation sites.
The advantages of the proposed method are the capabilities of remote regulation, releasing the analyte after detection, and repeated operation.
Since the selected in vivo NFI binding sites are located up to 5 kb from their TSS, which is a relatively large distance, NFI might act as well through some of the types of remote regulation, for instance by the establishment of a chromatin domain boundary that would prevent the propagation of a silencing chromatin structure towards the promoter [ 27, 38].
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The topology of DNA is finely tuned by topoisomerases [1] and plays a major role in many cellular processes in both prokaryotes and eukaryotes, such as remote gene regulation and site-specific recombination [2], [3].
More than 10 base pairs of the genome in higher eucaryotes are positioned in the interphase nucleus such that gene activation, gene repression, remote gene regulation by enhancer elements, and reading as well as adjusting epigenetic marks are possible.
For instance, KPCB company Airware has been very involved with the Federal Aviation Administration FAAA) to ensure they have an opportunity to shape regulation of remote-controlled aircrafts.
Brussels is a remote, unaccountable bureaucracy, imposing regulations beyond democratic control.
Ref. [13] proposed a voltage regulation algorithm assuming remote terminal units at each DG and feeder capacitor.
The present study was designed to investigate the potential regulation of limb remote ischemic post-conditioning (RIPC) on astrocytic plasticity in experimental cerebral ischemia-reperfusion injury.
These regions may be promoters of yet unidentified genes, or may represent remote control regions that participate in regulation of histone and histone-coregulated gene transcription initiation.
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