Further investigation of the roles of PR signaling in bone remodeling is needed.
Alteration of the extracellular matrix occurs when radical remodeling is needed, such as during organ development and tissue homeostasis, and is associated with changes in cell proliferation and differentiation.
Hence, more insightful study on the effects of PTH supplements on bone remodeling process is needed.
Such alterations would cause the release of factors associated with tethering connections between microtubule filaments, as well as the appearance of free minus ends, either of which could be a signal that a remodeling response is needed.
In order to maintain normal functions of bone and calcium homeostasis, bone remodeling process is needed to be taken into account.
The "immature" effector T cell may be on the path to differentiation, but may not have undergone chromatin remodeling, which is needed for stable T helper phenotypes.
further found somatic mutations in the H3.3-ATRX-DAXX chromatin remodeling pathway, which is needed for the incorporation of histone H3.3 into pericentromeric heterochromatin, in 44% of pediatric glioblastoma multiforme (GBM).
Thus, in order to determine more firmly whether TLR2 or 4 (or other TLR) are important for myocardial remodelling, more evidence is needed from knockout mice using different forms of cardiac injury, and longer times of observations of ventricular remodelling.
Further investigation of the underlying mechanisms of androgen action on cervical remodelling and myometrial contractility is needed.
When mammalian cells enter mitosis, dynein is needed to remodel the prophase MT network (Rusan et al., 2002), and at later stages dynein assists in organizing MTs to form focused spindle poles (Heald et al., 1996; Merdes et al., 1996).
