High field MR imaging showed changes that could be interpreted as bone remodelling (development of osteoporosis) which was evident in the compact bone at the peripheral margins and the spongious bone of the PSBs.
Matrix metalloproteinases (MMPs), also known as matrixins, are proteinases crucial in both normal tissue remodelling (development, wound healing) and in pathological conditions (arthritis, scar formation after MI, LV remodelling).
High-field MR imaging and histopathology provided evidence of interrelated changes of bone lysis at the axial aspect of the PSBs, inflammation with subsequent fibrous tissue (scar) formation of the adjacent ISL and additional remodelling (development of osteoporosis) of the compact bone at the periphery and the spongious bone of the PSBs.
The other overrepresented GO classes corresponded also to contraction, morphogenesis, remodeling, development, calcium homeostasis, immune function and metabolic processes.
Autophagy serves as a temporary survival mechanism that plays crucial roles in maintaining intercellular homeostasis, remodeling development, and regulating metabolism and the immune response, and is also associated with various human diseases and diverse stresses [ 3– 5].
Four processes - "Proteolysis: ECM remodeling," "Development: Blood vessel morphogenesis," "Proteolysis: Connective tissue degradation," and "Cell adhesion: Cell-matrix interactions" - are prevalent in the later stages of invasive cancerogenesis when the tumor is large in size.
Bone remodelling during development could influence the shape of the vertebrae, including the neural foramen.
TERRA functions that are emerging suggest important roles in the regulation of telomerase and in orchestrating chromatin remodelling throughout development and cellular differentiation.
The top commonly affected GeneGo pathway maps (GGPM), shown in Fig. 2B, included immune response, cytoskeleton remodeling, development, cell cycle and transcriptional regulation.
Fungal chitinases from family GH18 are essential for FCW remodelling during growth and development [ 59].
Lu, P., Takai, K., Weaver, V. M. & Werb, Z. Extracellular matrix degradation and remodeling in development and disease.
