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Epigenetic regulation of gene expression may occur by histone deacetylation and methylation, cytosine methylation, and chromatin remodeling 1, 2. Altered epigenetic regulation affects normal gene transcription and is potentially tumorigenic.
Chronic allergic asthma is a complex disease provoked by aeroallergen exposure, which promotes Th2-polarized airway inflammation (13) and airway remodeling (1), for which a number of possible underlying mechanisms have been proposed (7, 12, 19, 20, 22, 26, 30).
Potena et al. have shown that in heart transplant patients managed by a pre-emptive strategy, asymptomatic CMV infection was associated with an increased risk of developing CAV, defined as abnormal coronary remodeling 1 year after HTx [ 6].
A significant number of these genes are involved in chromatin remodeling e.g. Curly leaf like gene, chromatin remodeling 1 and 17, several core histone genes, methyltransferase1 and histone acetyltransferase genes and several DNA binding proteins like HTB2, HTB11, HTA2, 6 and 12.
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Both approaches are illustrated in a recent paper on bone remodeling [4].
Furthermore, SE has been used to predict left ventricular remodeling [19] and response to reperfusion strategies [20].
Zoledronate also improves the amount of bone in the metaphysis during bone healing, suggesting a positive effect on remodeling [8].
Amongst their many functions, Calpains are involved cytoskeleton remodeling [1].
The highly organized structure of the ECM is essential for cell and tissue morphogenesis and remodeling [1].
Osteopontin (OPN) is a phosphoglycoprotein that has important physiological functions in bone remodeling [1], immune response and inflammation [2], [3].
Wound healing, the tissue repair process, is accomplished through the following 3 stages: inflammation, proliferation, and remodeling [1].
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