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These cytoskeletal features not only enable the myofibroblast to remodel and contract the extracellular matrix but to adapt its activity to changes in the mechanical microenvironment.
20 Lastly, myofibroblasts show both fibronexus junctions with other cells and specialized junctional complexes with the ECM; these large mature focal adhesions allow them to make strong attachments, contract and remodel the ECM, and provide a means of transducing mechanical force in the tissue.
If the remodeling also affects the upper chambers, the atria, it can throw off the electrical pathways that generate the "contract now" signals that precede each heartbeat.
Here's the contract.
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The contract worked.
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Check the contract.
Terminate the contract.
Describe the contract.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com