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Although the mechanism of the resistance to mTOR inhibitor is unclear, disease progression after initial everolimus treatment may be explained by evolving progression mainly due to proliferation of the remnant resistant subclones.
In the context, there would remain relatively sensitive subclones serving a key role in maintaining the stable disease on everolimus re-treatment, These subclones might exhibit higher sensitivity to everolimus than remnant resistant subclones, but not higher than the most sensitive subclones previously responded in initial treatment.
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They had recognized that blocky mesas and conical monadnocks are subtractive features, remnants of resistant rock left after aeons of sculpting by agents of erosion.
Given that nuclear envelope remnants are resistant to detergent solubilization, we predicted that they would be enriched in cholesterol.
Monadnocks are left as erosional remnants because of their more resistant rock composition; commonly they consist of quartzite or less jointed massive volcanic rocks.
The "detergent resistant" properties of the remnants may be due to the association of the membrane with various proteins or chromatin attachment [37] and to the presence of the liquid-ordered state.
Currently, these platinum-resistant tumour remnants are being further characterised.
Furthermore, the activation of LRP (one of the hepatic receptors responsible for chylomicron remnant uptake) by insulin is abolished in insulin-resistant mice [ 26].
In contrast, most mouse strains, including C57BL/6, are resistant to the development of FSGS via the remnant kidney model.
Thus, the conservation and restoration of staghorn coral populations will have to be achieved through the local protection of remnant populations and aggressive strategies aimed at propagating and transplanting WBD resistant genotypes to reefs.
Here we investigated whether the remnant living cells in the late-stage tumors exhibited the characteristics of CSCs, which are supposed to be resistant to environmental stresses for tumor viability.
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