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Clinical courses were classified as remission, response, and no response.
The LITHE study only reports ACR-50 and DAS28 defined remission response rates at 52 weeks.
The remission response in the PsA patients appears to be most strongly associated with the patient-derived outcome measure of function - HAQ.
Remission, response and symptom improvement scores on the Hamilton Depression Scale, Montgomery Asberg Depression Rating Scale and Clinical Global Impressions-Severity scales were extracted.
Partial remission response also increased with adalimumab treatment from 22 to 39%, indicating persistent improvement with continued treatment at 104 weeks.
At week 12, more CZP patients also achieved an ASAS40 response, ASAS5/6 response, and ASAS partial remission response versus placebo (p<0.001) (figure 2A).
Similar(44)
In all cases, cure responses were for WEPT and OIDT, which satisfied the model energy balances of Eq. (2.1.7), whereas remission responses were similar for all LIDT and OIDT that satisfied Eq. (2.1.1).
20 The ASAS40, ASAS 5/6, and ASAS-defined partial remission responses 21 were also evaluated.
Furthermore, adalimumab-treated patients had significantly higher ASAS40, ASAS5/6, and partial remission responses at both time points compared with placebo.
The percentage of patients achieving ASAS20, ASAS40, ASAS 5/6 and ASAS partial remission responses was sustained from week 24 to up to 2 years of adalimumab exposure (fig 1A and B).
The BASDAI 50, ASAS20, ASAS40, ASAS 5/6 and ASAS partial remission responses that were achieved during the initial 24-week, double-blind period of ATLAS were sustained for up to 2 years of treatment.
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