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About a third of the sample, with no differences between males and females, had one or more active periods each year; another third had periods of remission exceeding one year; in the remaining, the frequency of active periods was erratic.
Two were excluded because of clinical remission exceeding 5 years.
13 SMD symptoms must begin before age 12, occur for ≥1 year without remission exceeding 2 months, and cause functional impairment in 2 settings.
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Once a complete remission exceeds 5 years, complication screening might occur at a reduced frequency (depending on the status of each complication).
When complete remission exceeds 5 years, goals appropriate for a patient without diabetes could be considered, as long as the patient remained without recurrence of diabetes and without cardiovascular events.
However, despite a pathologic complete remission rate exceeding 40%, survival of patients with this phenotype was reported in several studies to be shorter than for those with receptor-positive tumors [ 1].
In recent trials, DAS28 remission rates exceeded ACR70 response rates [ 23- 26], meaning that more patients achieved a state of DAS28 remission than the proportion of patients reaching a decrease of 70% or higher in tender and swollen joints.
Long-term follow-up from [41] 33 cases 30% experienced at least 1 episode of complete attack remission (attack-free period exceeding 1 month).
Long-term follow-up from [41]30%% experienced at least 1 episode of complete attack remission (attack-free period exceeding 1 month) Fig. 2 Risk of bias summary of randomized-controlled studies.
The medical treatments used as second-line therapy have undergone few randomised controlled trials and a systematic review covering nearly 700 patients showed that complete remission rates rarely exceed 15% and few of the individual studies have sufficiently large numbers of truly refractory patients to make a definitive recommendation [ 22].
Remission periods (attack-free periods exceeding one month, per the ICHD 3 (beta) definition) occurring during the 24-month study period were characterized.
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