Remarkably, previous studies have postulated the occurrence of latitudinally arrayed dinosaur "provinces," or "biomes," on Laramidia.
Remarkably, previous studies suggested that calcium depletion and ER stress can also affect hypoxic signaling either via interference with the regulation of HIF [26] [28] or via HIF-independent pathways [44].
Remarkably, previous studies in the gerbil could not detect a decline in DA fibre densities in other brain areas than the PFC in old animals compared to adult ones [ 9, 10].
Remarkably, previous in vitro results have shown that NM II is important for turning in response to boundaries of substrate-bound laminin-1 (Turney and Bridgman, 2005) and that pharmacological inhibition or genetic silencing of NM II leads to disorganization of the growth cone, allowing rapid axon extension over inhibitory substrates (Hur et al., 2011).
Remarkably, our previous studies of Mdr2-KO mice [15] demonstrated that chronic liver disease at an early precancerous stage in this HCC model shares many features characteristic of chronic HCV infection and HCV-induced cirrhosis in patients: hepatocyte G1 arrest and up-regulation of genes Mcm2 [30], Cxcl9, Lgals3, Iqgap1, Lum, Col6a3, Igfbp7, Vim, Ablim, Mpp1 [31], Igfbp1, Itgb1, Jun, Ctgf [32].
The first molecular analyses on the phylogeny of Mammalia, using mitochondrial genes have remarkably challenged previous morphological hypotheses on the relationship among mammalian groups [ 45].
Remarkably little previous work has been carried out to investigate the overall biodistribution of bimodal liposomes for imaging, or the effects of changes in formulation on biodistribution.
Despite these concerns, and the potential use of quantitative PCR (qPCR) data in clinical decision-making, remarkably few previous studies have undertaken detailed technical evaluation of the performance of PCR methods for assessing HPV load and physical state.
Remarkably, our previous study on the canine modal showed that when one side of hypogastric nerve was severed, the other side of hypogastric nerve could compensate for the genitourinary functional loss to a normal level.
Remarkably, in previous studies the highly frequent lever-pressing behaviors were typically induced by electrical stimulations, during which all the neural populations within the VTA were activated compulsively, making it unclear whether any type of subpopulations was involved in the reward learning behaviors.
Remarkably, whereas previous GWASs for other complex traits with far smaller sample sizes had discovered multiple novel variants, only one locus on chromosome 15, which harbors the cluster of nicotinic acetylcholine receptor genes CHRNA3-CHRNA5-CHRNB4, has been robustly associated with CPD across multiple GWAS of smoking [ 2- 7].
