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In our in vitro system, all three Aire+ cell lines remarkably increased expression of IPSM-specific subunits, such as structural subunits (β1i, β2i and β5i) by ∼50× and regulatory subunits (PA28α, PA28β and PA28γ) by ∼6× toward reaching confluent state (Fig. 3D).
Our previous study has shown miR-200c in the blood can distinguish with significant specificity and sensitivity, patients with gastric cancer from healthy controls and remarkably, increased expression levels of miR-200c in blood were significantly associated with poor progression-free and overall survivals in gastric cancer patients [ 21].
Murrell [ 89], in experimental rat models developed to evaluate Achilles tendon and rotator cuff healing, found remarkably increased expression of all three NOS isoforms after surgical excision (iNOS at days 4 and 7, eNOS at day 7 and bNOS at day 21).
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Simulated microgravity conditions on a three-dimensional clinostat remarkably increased gene expression of PsPIN1 and PsAUX1 in the hook and the internodes of pea epicotyls, but the increase in PsPIN2 was less.
Remarkably, increased survivin expression was observed in the most common human neoplasms, including oesophageal cancer, gastric cancer, colorectal carcinoma, non-small cell lung cancer, bladder cancer, neuroblastoma and lymphoma (Adida et al, 1998, 2000; Kawasaki et al, 1998; Lu et al, 1998; Monzo et al, 1999; Swana et al, 1999; Sarela et al, 2000; Kato et al, 2001).
All atTOC159 homologous genes have increased expression level in flowers and siliques, especially a remarkably higher expression level of atTOC159 in later stage of fruit development.
All four genes have increased expression level during flower and fruit development, particularly a remarkably high expression level of atTOC159 in later stage of fruit development.
Remarkably, we found that 81% of direct target genes do not show increased expression levels in an NMD mutant, presumably due to feedback regulation.
Only five displayed increased expression.
Paradoxically, there was increased expression of DNAJC3.
Increased expression of adiponectin was also detected.
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