A study of the thermodynamic properties of the variants shows that the structure of UCH-L1 is remarkably tolerant to incorporation of bulky tryptophan side chains.
Introduction of electron withdrawing substituents on phenyl rings oftriphenylphosphate (k m) remarkably promotes catalytic activity, while bulky substituent isopropyl at 2-position (h) has beneficial influence on regioselectivity.
Williams is remarkably agile and quick for his bulky frame, but Umenyiora made him spin like a top.
DOI: http://dx.doi.org/10.7554/eLife.03496.006 Remarkably, although the negatively charged and bulky amino acid substitutions of Cys63 (Kar2-C63D/F/Y/W) protect against hyper-oxidizing conditions, these alleles lack essential BiP activity.
Apple's 5K iMac doesn't look any different from the rest of the lineup on the outside – the tapered design it introduced in late 2012, which is thick in the middle of the back to house the bulkiest internals, and then tapers to a remarkably thin 5mm on the edge, is still in use here.
Remarkably, in the center of the FG-loop lies a bulky tryptophan amino acid residue, around which exquisite hydrogen bonds and hydrophobic interactions make the loop a relatively rigid entity (Wang et al., 1998).
The device really is remarkably light; you'd expect such a powerhouse to be heavy and bulky, but it's quite petite.
Remarkably, Apollo 11 did so with onboard navigational equipment that was as bulky and primitive as computers were at the time.
Similarly, he also seems to be approaching his stint as Mark as humbly and casually as possible; by all accounts, he has been remarkably egoless in taking on a role that requires him to don a bulky sweater, do a goofy tango, suffer romantic rejection and generally play against type.
Remarkably, the moderate isolated yield was obtained for the challenging coupling of the amine bearing very bulky groups.
