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Preclinical models based on patient-derived xenografts have remarkable specificity in distinguishing transformed human tumor cells from non-transformed murine stromal cells computationally.
We observe remarkable specificity in the actions of natural selection.
MBD proteins are associated with hypermethylated CpG island promoters of tumour-suppressor genes and their transcriptional silencing (Esteller, 2005a), showing remarkable specificity in vitro (Fraga et al, 2003) and in vivo (Ballestar et al, 2003; Klose et al, 2005).
This motif that has been reported to bind lipids and to act as a curvature sensor in vitro [ 17] exhibits a remarkable specificity in vivo: it accumulates at discrete regions of the cis-cisternae and also associates with some ER exit sites.
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The novel targeting vectors transduced HK with high efficiency and a remarkable specificity even in mixed cultures of HK and feeder cells.
The results demonstrate a remarkable specificity of interference in motor learning.
Patient-based sensitivity was overall 6/13=46 % for FDOPA PET and 7/14=50 % for FDG PET; an important point was the remarkable specificity of FDOPA, in contrast to CT, MRI, SRS and FDG, leading to a very high positive predictive value (PPV).
Before IdeS can cleave IgG in the heavy chain (see Fig. 1A) the enzyme has to bind to the Fc region of the antibody, and the remarkable specificity of IdeS lies in this protein-protein interaction [15].
We were surprised, however, at the remarkable specificity of transgene expression in a subset of prostate epithelial cells.
The remarkable specificity of LTP trafficking in the Drosophila CNS provides a novel framework for understanding information flow between the circulation and the brain.
The Genepaint and Genomics Institute of the Novartis Research Foundation GNFF) GeneAtlas (Su et al., 2004) databases, which contain transcriptional information for embryo sections and 61 mouse tissues, respectively, confirmed the remarkable specificity of H2be expression in the MOE and VNO.
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