Sentence examples for remarkable specificity for from inspiring English sources

Ideally the chemicals offer remarkable specificity for a particular signaling pathway and exhibit negligible off-target effects.

In this manner variants of the BBP were engineered which exhibit high affinity and remarkable specificity for haptens like fluorescein and digoxigenin.

Primary selection of ligands against Ras with mRNA display resulted in an intrabody (termed RasIn1) that binds with a KD of 2.1 μM to H-Ras(G12V) (GTP), excellent state selectivity, and remarkable specificity for K- and H-Ras.

But, certain ATP proximal functional residues showed remarkable specificity for DDX3X.

All DUBs tested have remarkable specificity for ubiquitin.

Other phosphoinositides did not cause this effect, demonstrating a remarkable specificity for PI5P.

These data illustrate the remarkable specificity of selection for grain methionine concentration, whereby the largest changes were observed for methionine, and observed differences for other amino acids were much smaller.

The remarkable specificity of Endo-S for native IgG has also been exploited for engineering of IgG glycoforms as described below.

71 Kinase profiling assays on almost 60 different kinases revealed a remarkable specificity of this compound for PDK1, inhibiting PDK1-dependent phosphorylation of Akt Thr308 in vitro and in vivo.

Kinetic measurements confirmed the remarkable specificity of CDG-3 for BlaC (Table S1): the catalytic efficiency of BlaC (2.4×10 s−1  m−1) for the hydrolysis of this probe was 120 000-fold higher than that of TEM-1 Bla (2 s−1  m−1) and 800 000-fold higher than of Pen (0.3 s−1  m−1).

Differential tissue specific regulation of genes by hypoxia provides a putative reason, for the remarkable specificity of VHL to produce invasive renal tumours.