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The aptamer variant showed remarkable selectivity for adenosine over the other ribonucleosides.
It was capable to operate in CHEF mechanism toward Co2+ and showed high sensitivity and remarkable selectivity for Co2+ with 10-fold fluorescence enhancement.
A study of the biochemical interactions of the biotin probe suggests that melampomagnolide B derives its remarkable selectivity for leukemic cells over normal hematopoietic cells from its unique ability to exploit biochemical differences between the two cell types.
Compounds 12d and 12k were the most potent AChE inhibitors with IC50 values of 11 and 13 nM, respectively, while 6j (IC50 = 17 nM) proved to be the most active inhibitor against BuChE with remarkable selectivity for BuChE over AChE.
Wild type (WT) arrestin-1 has remarkable selectivity for active phopshorylated rhodopsin (P-Rh*), demonstrating many times lower binding to active unphosphorylated (Rh*) and inactive phosphorylated (P-Rh) forms, and virtually no binding to inactive unphosphorylated rhodopsin (Gurevich and Benovic, 1992 , 1993.
The designed fluorescent sensor possesses remarkable selectivity for cyanide ion over other anions such as Cl−, Br−, F−, I−, IO3−, ClO4−, BrO3−, CO32 −, NO2−, NO3−, SO42 −, S2O42 −, C2O42 −, SCN−, N3−, citrate and tartarate with negligible influences on the cyanide detection by fluorescence spectroscopy.
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Although none of the new compounds were more potent inhibitors than the reference inhibitor 1, this study helped to completely define the structural requirements of the active site of BHMT and revealed the remarkable selectivity of the enzyme for homocysteine.
Crystallography and enzymology involving WT and Ala190 uPA were used to calculate free energy binding contributions of hydrogen bonds involving the Ser190 hydroxyl group (OγSer190) responsible for the remarkable selectivity of 6-halo-5-amidinoindole and 6-halo-5-amidinobenzimidazole inhibitors toward uPA and against natural Ala190 protease anti-targets.
Among the various complexes formed by CHL1, Hsc70, CSP and αSGT, SNAP25 and VAMP2 induce chaperone activity only in CHL1/Hsc70/αSGT and CHL1/CSP complexes, respectively, indicating a remarkable selectivity of a presynaptic chaperone activity for proteins of the exocytotic machinery.
The electrochemical experiments exhibited a remarkable selectivity of the prepared sensor towards IMD.
There is a remarkable selectivity of this phenotype.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com