However, it has been noted for over 100 years that immunological manipulations alone can similarly produce some remarkable regressions of cancer, apparently quite separately from the standard presumed mechanisms of cell death from cytotoxic and antiangiogenic agents.
Although a total surgical debridement of the lesions could not be performed, it is remarkable that regression of the disease could be achieved with medical therapy alone.
We have previously reported that viral colonization of human breast tumor xenografts in nude mice leads to a remarkable tumor regression over time following a characteristic three-phase growth pattern [ 16].
The significant improvement over the existing soil map is remarkable because the regression model was calibrated with the existing soil map and uses no additional soil observations.
Coley systematically applied Streptococcus pyogenes extracts – later called 'Coley's toxin' – to cancer patients and achieved a remarkable rate of regressions.
Therapy with engineered T cells has also demonstrated remarkable tumor control and regression in human trials.
Heterogeneity in the clinical behaviour of these tumors is remarkable, ranging from spontaneous regression to aggressive clinical course and death due to disease.
Remarkable cases of complete regression of metastatic melanoma and other cancers with prolonged survival, with or without therapeutic intervention, are noteworthy events and represent highly instructive natural clinical experiments.
