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We observed for example remarkable interindividual differences in the subset of IFN-γ producing CD56+ cells in response to IL-23 in combination with IL-1β or IL-18.
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Wide interindividual differences in metabolism result in different DNA adduct levels.
These data were obtained in tissues from different individuals and possible interindividual differences cannot be excluded.
Large interindividual differences in CIM were reported regarding different surfactants and solvents.
Interindividual differences in TYMS expression may be responsible for the different clinical responses to 5-FU.
Because of interindividual differences in human microbiota, resveratrol metabolite production in the gut differs.
However, the curves for different subjects did not intersect, thus showing comparatively constant interindividual differences.
Interindividual differences in toxicokinetics present challenges in comparing results of metabolite measurements among different people.
Ivanov, M., Kacevska, M. & Ingelman-Sundberg, M. Epigenomics and interindividual differences in drug response.
Interestingly, Bode, et al.33 showed that interindividual differences in gut microbiota influenced resveratrol metabolism (Fig. 1).
Interindividual variability in expression of these isoforms would cause interindividual differences in drug response, toxicity and cancer susceptibility.
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