On the other hand, two remarkable domains are included in the NS5A region: the V3 domain, seemingly involved in responsiveness to interferon [70], [84], and PKR-BD, which contains the putative interferon sensitivity determining region (ISDR) and seems to be involved in blocking the cellular antiviral response induced by interferon [61], [85] [87].
The G-patch is the only remarkable domain for GPATCH2, Spp2, Gno1, and Ntr1.
H3K27me3 ChIP on these samples confirmed the remarkable domain opening, predicted by the domain model (Fig. 8c through h).
In contrast, when the enzyme was simulated under protonation conditions corresponding to alkaline medium, we observed a remarkable domain separation, with domain center-of-mass distances of up to 24 Å (Fig. 5).
(2008) describe the discovery of a cryptic FHA module with a remarkable 'split' domain architecture in Pellino-family proteins, with some intriguing implications for understanding their role in Toll and IL-1 receptor signaling.
The key to this remarkable inter-domain genetic connection is the genus Spirochaeta.
Another remarkable two-domain protein example is matrix metalloproteinase 1 (MMP-1), an enzyme that can cleave collagen despite the fact that collagen's quaternary and superquaternary organization conceals the cleavage site.
It is remarkable that young domains found in otherwise highly conserved proteins (containing Old domains) also evolve very rapidly, further stressing the importance that the time elapsed since a protein sequence originated has on its evolutionary rate.
The other multidomain protein of Monosiga shows a remarkable conservation of domains and of their linear arrangement with members of the animal Peregrin family.
On the contrary, a remarkable diversity of domain architectures was observed when considering HyHKs (respectively 19, 19, 16, 13 distinct domain architectures in A. lipoferum 4B, Azospirillum sp. B510, A. brasilense Sp245 and CBG497) (Table 4).
Option one assumes a remarkable switch in domain selectivity from one task context to another, and we can think of no evidence for such a switch either in the anterior temporal lobe or indeed anywhere else in the brain.
