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This observation indicates a remarkable delayed secretion of the mutant FIX and, taking into account the one day half-life of FIX [19], provides a plausible explanation for the very low amount of circulating FIX in the patient.
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As illustrated in Fig. 4, all cases except "off-set SAGD 3 m" case have initiated to produce oil after a remarkable delay.
If the stress-to-strength ratio becomes too high, or if faulted rock with high water pressure is unexpectedly encountered, the "unexpected events" may have a remarkable delaying effect on TBM.
Together, CXR results for SO2 vaccination suggest a remarkable delay in the onset of TB lung disease after high-dose infectious challenge.
However, it induced a remarkable delay in S/G2 phase transit with entry into mitosis in HCT116 p53 −/− cells.
These two disease categories consequently show remarkable delays in reporting; for shigellosis, we found even higher percentages of delay than were found in other studies [ 6- 8].
However, there was a remarkable delay in treatment initiation before the diagnosis, which was also observed in other studies on rapid tests for MDR-TB diagnosis [ 10, 14].
CSF analysis, which was performed with remarkable delay in our series, showed a significant protein increase due to severe B-CSF B damage in all patients.
In the literature, most of the reports highlight that there is always a remarkable delay of establishing accurate diagnosis as a result of misdiagnosis of asthma [ 1, 5, 7].
Although this work had been carried out in complex medium it is unlikely that the absence of supplements in the medium used for the current study would cause such a remarkable delay in regulating global gene expression.
Although pretreatment with 2 mM NAC did not prevent cell loss induced by celastrol (LD50: 3.38±0.11 μM without NAC versus 3.55±0.19 μM with NAC pretreatment; P=0.0856), co-treatment with NAC led to a remarkable delay in this regard (LD50: 12.6±161 μM; P=1.6 × 10−23), suggesting that thiol reactivity is pivotal to celastrol's mechanism of action in glioblastoma.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com