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HF10 SCS has shown remarkable clinical efficacy in human refractory back pain [13, 15].
Remarkable clinical efficacy, durable response and low toxicity of programmed death 1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint blockades have been observed in various malignancies.
Antibodies targeting CTLA4 and PD-1/PD-L1 have shown remarkable clinical efficacy in metastatic melanoma [ 1, 2, 5].
In the past decade, a series of potent new biologic therapeutics have demonstrated remarkable clinical efficacy in several autoimmune diseases, including rheumatoid arthritis (RA).
Despite the remarkable clinical efficacy and established involvement of effector CD8 T cells, the knowledge of the exact peptide-MHC complexes recognized by T cells on the tumor cell surface is limited.
Based on the current understanding of "cancer immunity" mentioned above, cancer immunotherapy attempts an active intervention for cancer immune responses, which change over time and space, and has started to reveal remarkable clinical efficacy in some trials.
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8 15 The clinical efficacy of bortezomib is remarkable considering that all patients had been refractory to immunosuppression before.
In concordance with the clinical efficacy observed in ALK+ pts, the remarkable efficacy of alectinib has been demonstrated in experimental models of IC metastases [ 26, 27].
Interestingly, crizotinib caused tumors to shrink in the pleural carcinomatosis model, but not in bone and brain metastasis models, whereas alectinib showed remarkable efficacy in all three models, indicative of the clinical efficacy of these ALK inhibitors.
In this respect it is remarkable that obesity is often found in comorbidity with MD and particularly so with the atypical depression subtype [68], while clinical efficacy of antidepressants is reduced in obese individuals [69].
They have 25 years building spirometry with a real level of clinical efficacy.
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