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Although survival has slowly increased in the past years, the prognosis of these patients remains unfavourable.
Although the application of target-directed therapeutics improved the outcome of patients with metastatic ccRCC their prognosis remains unfavourable [ 5].
Despite advances in the systemic treatment of metastatic colorectal cancer (mCRC), the long term prognosis of patients with (mCRC) still remains unfavourable unless a resection can be performed.
If the cervix remains unfavourable the morning following cervical ripening, the patient's clinician decides upon further management (usually either further PGE2 or insertion of Foley catheter).
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Both could potentially be factors that constrain the growth of firms.13 The structure of exports is unfavourable and remains unchanged throughout the last decade.
Meanwhile, among voters, the idea that failing to strike any sort of deal with the EU would be preferable to signing an unfavourable one remains remarkably persistent, with over half of Leavers claiming, even despite the warnings, that they would prefer No Deal to any other option.
Nevertheless, a large group of patients with distinct clinico-pathological profile and unfavourable outcome remains uncharacterized.
Yet, the evolutionary mechanism determining the individuals' willingness to sever unfavourable ties remains unclear.
Whether the rest of top-ranked miRNAs of the 14q32.31 set, not considered in the present study, could help to discriminate unfavourable neuroblastoma remains to be investigated.
Conversely, T119M TTR is a kinetically stable variant whose tetramer-monomer transition is energetically very unfavourable, thus it remains as a tight homotetramer in solution [ 41].
Therefore, it remains unclear whether a demanding period such as unfavourable environmental conditions or the extra energetic demand incurred to support catch-up growth, results in an elevation of corticosterone levels in young altricial birds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com