In a news-heavy year dominated by the economy, the faltering coalition and an unprecedented summer of sport (although Olympics junkies were better served by 5 Live), Radio 4's Today programme remains required listening.
A multicenter prospective study assessing a large cohort of patients using serial echocardiographic examinations remains required to confirm the prognostic value of LV diastolic dysfunction in septic shock.
However, the currently accepted diagnostic work-up of RCD remains required, pending prospective serum studies including larger series of patients.
Recent advances have clearly shown that the successful investigation of ancient human remains requires the application of a multitude of analytical techniques, depending on the available tissue and its degree of conservation, but also on the applicable techniques [ 2].
However, the lack of fossil remains requires denser sampling and the incorporation of multiple markers to explain the relationships of present-day geographically distant groups, which probably have been in vicinity in the past.
The use of non invasive ventilation (NIV) has dramatically reduced the need of endotracheal intubation (EI) [ 1], but EI remains required in case of failure of NIV or initially life-threatening acute respiratory failure (ARF).
In any case regular validation with phenotypic DST and clinical response remains required, since adding more markers will only improve sensitivity, if new strains (carrying new drug resistance conferring mutations) are introduced in the setting.
Articulation of the remains requires different analytical strategies, as commingled or disturbed remains are associated with bodies or body parts by pair matching, reconstruction, or a process of elimination.
Nevertheless, the test remains invasive, requiring an angiogramme.
The prognostic role of dissection extent in ATBAD remains unclear, requiring further investigation to determine its effect on natural history.
