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Although most patients benefit from abortive and preventive drugs, a subgroup of patients remains refractory to treatment.
Paroxysmal atrial fibrillation is a common occurrence in patients following thoracic surgery and in some patients remains refractory to medical therapy.
The patient remains critically ill and her MAI remains refractory to the multidrug treatment regimen.
M.CviPI enzyme methylates accessible DNA at GpC sites, whereas nucleosome-bound DNA is inaccessible and remains refractory to GpC methylation.
Progression of advanced pulmonary fibrosis that remains refractory to medical management may eventually require single- or double-lung transplantation.
In spite of this progress in treatment options, a relevant subset of patients remains refractory to first rTKI therapy.
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Peripheral nerve injury still remains a refractory challenge for both clinical and basic researchers.
The vast majority of these patients suffer from medication overuse headache which can and should be alleviated by detoxification, but a subset remains as refractory chronic migraine (RCM) [6].
Metastatic melanoma is a clinically heterogeneous disease that responds unpredictably to treatment, and remains largely refractory to current therapeutic options.
Nevertheless, a significant proportion of patients remains either refractory to or relapses after R-CHOP therapy.
No clear consensus exists on the treatment of choice, and FM remains relatively refractory to treatment [ 4].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com